MED28 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H204 |
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Clone Names | 81028083 |
Gene ID | 80306 |
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Other Names | Mediator of RNA polymerase II transcription subunit 28, Endothelial-derived protein 1, Mediator complex subunit 28, Merlin and Grb2-interacting cytoskeletal protein, Magicin, Tumor angiogenesis marker EG-1, MED28, EG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MED28 |
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Synonyms | EG1 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. |
Cellular Location | Nucleus. Cytoplasm. Membrane; Peripheral membrane protein Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated |
Tissue Location | Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
References
Beyer, K.S., et al. J. Biol. Chem. 282(44):32152-32157(2007)Lu, M., et al. Cancer Biol. Ther. 6(6):936-941(2007)Lu, M., et al. Int. J. Oncol. 29(4):1013-1018(2006)Lee, M.F., et al. Biochem. Biophys. Res. Commun. 348(3):826-831(2006)Lee, M.F., et al. Biochem. Biophys. Res. Commun. 348(3):826-831(2006)
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