|Other Names||Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17A, CTLA8, IL17|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).|
|Tissue Location||Restricted to activated memory T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a proinflammatorycytokine produced by activated T cells. This cytokine regulates theactivities of NF-kappaB and mitogen-activated protein kinases. Thiscytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with severalchronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis.
Chen, X., et al. Cancer Sci. 101(11):2384-2390(2010)Dart, M.L., et al. Circ. Res. 107(9):1106-1116(2010)Marwaha, A.K., et al. J. Immunol. 185(7):3814-3818(2010)Crome, S.Q., et al. J. Immunol. 185(6):3199-3208(2010)Weng, X.M., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 24(1):42-44(2010)
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