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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   IL17A Antibody (Center) Blocking peptide   

IL17A Antibody (Center) Blocking peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession Q16552
Clone Names 90723193
Peptide ID 90723193
Additional Information
Gene ID 3605
Other Names Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17A, CTLA8, IL17
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL17A
Synonyms CTLA8, IL17
Function Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Cellular Location Secreted.
Tissue Location Restricted to activated memory T-cells.
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a proinflammatorycytokine produced by activated T cells. This cytokine regulates theactivities of NF-kappaB and mitogen-activated protein kinases. Thiscytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with severalchronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis.

References

Chen, X., et al. Cancer Sci. 101(11):2384-2390(2010)Dart, M.L., et al. Circ. Res. 107(9):1106-1116(2010)Marwaha, A.K., et al. J. Immunol. 185(7):3814-3818(2010)Crome, S.Q., et al. J. Immunol. 185(6):3199-3208(2010)Weng, X.M., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 24(1):42-44(2010)

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$ 80.00
Cat# BP12918c
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