|Other Names||Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.|
|Tissue Location||Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells|
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This gene encodes a member of the serine proteinaseinhibitor (serpin) superfamily. This member is the principalinhibitor of tissue plasminogen activator (tPA) and urokinase(uPA), and hence is an inhibitor of fibrinolysis. Defects in thisgene are the cause of plasminogen activator inhibitor-1 deficiency(PAI-1 deficiency), and high concentrations of the gene product areassociated with thrombophilia. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Ma, Z., et al. Biochem. Biophys. Res. Commun. 400(4):569-574(2010)Ince, D.A., et al. Genet Test Mol Biomarkers 14(5):643-647(2010)Bern, M.M., et al. Clin. Appl. Thromb. Hemost. 16(5):574-578(2010)Markl, B., et al. J Surg Oncol 102(3):235-241(2010)de Haas, E.C., et al. Cancer (2010) In press :
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