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SERPINE1 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P05121
Clone Names 90713244
Peptide ID 90713244
Additional Information
Gene ID 5054
Other Names Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINE1
Synonyms PAI1, PLANH1
Function Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Cellular Location Secreted.
Tissue Location Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Research Areas
Citations (0)

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Background

This gene encodes a member of the serine proteinaseinhibitor (serpin) superfamily. This member is the principalinhibitor of tissue plasminogen activator (tPA) and urokinase(uPA), and hence is an inhibitor of fibrinolysis. Defects in thisgene are the cause of plasminogen activator inhibitor-1 deficiency(PAI-1 deficiency), and high concentrations of the gene product areassociated with thrombophilia. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.

References

Ma, Z., et al. Biochem. Biophys. Res. Commun. 400(4):569-574(2010)Ince, D.A., et al. Genet Test Mol Biomarkers 14(5):643-647(2010)Bern, M.M., et al. Clin. Appl. Thromb. Hemost. 16(5):574-578(2010)Markl, B., et al. J Surg Oncol 102(3):235-241(2010)de Haas, E.C., et al. Cancer (2010) In press :

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$ 80.00
Cat# BP12919c
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