|Other Names||Glycerol kinase, GK, Glycerokinase, ATP:glycerol 3-phosphotransferase, GK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme in the regulation of glycerol uptake and metabolism.|
|Cellular Location||Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm|
|Tissue Location||Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the FGGY kinase familyof proteins and encodes glycerol kinase. Glycerol kinase is a keyenzyme in the regulation of glycerol uptake and metabolism. Itcatalyzes the phosphorylation of glycerol by ATP, yielding ADP andglycerol-3-phosphate. Defects in this gene are the cause ofglycerol kinase deficiency (GKD). Alternatively spliced transcriptvariants encoding different isoforms have been identified.
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Zhang, Y.H., et al. Pediatr. Res. 59 (4 PT 1), 590-592 (2006) :Ohira, R.H., et al. Biochem. Biophys. Res. Commun. 331(1):239-246(2005)Stepanian, S.V., et al. Mol. Genet. Metab. 80(4):412-418(2003)Hellerud, C., et al. Clin. Chem. Lab. Med. 41(1):46-55(2003)
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