GK Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P32189 |
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Clone Names | 91013016 |
Gene ID | 2710 |
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Other Names | Glycerol kinase, GK, Glycerokinase, ATP:glycerol 3-phosphotransferase, GK |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GK (HGNC:4289) |
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Function | Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn- glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis. |
Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Nucleus. Cytoplasm, cytosol. Note=Glycerol kinase activity is more cytosolic in some tissues. It probably represents the expression of isoforms lacking a transmembrane domain [Isoform 4]: Cytoplasm, cytosol. Note=In adult tissues, such as liver the glycerol kinase activity is more cytosolic. It probably represents the expression of this isoform which lacks a transmembrane domain |
Tissue Location | [Isoform 2]: Widely expressed in fetal and adult tissues. [Isoform 4]: The sole isoform expressed in adult liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the FGGY kinase familyof proteins and encodes glycerol kinase. Glycerol kinase is a keyenzyme in the regulation of glycerol uptake and metabolism. Itcatalyzes the phosphorylation of glycerol by ATP, yielding ADP andglycerol-3-phosphate. Defects in this gene are the cause ofglycerol kinase deficiency (GKD). Alternatively spliced transcriptvariants encoding different isoforms have been identified.
References
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Zhang, Y.H., et al. Pediatr. Res. 59 (4 PT 1), 590-592 (2006) :Ohira, R.H., et al. Biochem. Biophys. Res. Commun. 331(1):239-246(2005)Stepanian, S.V., et al. Mol. Genet. Metab. 80(4):412-418(2003)Hellerud, C., et al. Clin. Chem. Lab. Med. 41(1):46-55(2003)
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