|Other Names||Zinc finger CCHC-type and RNA-binding motif-containing protein 1, U11/U12 small nuclear ribonucleoprotein 31 kDa protein, U11/U12 snRNP 31 kDa protein, U11/U12-31K, ZCRB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus, nucleoplasm|
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Provided below are standard protocols that you may find useful for product applications.
Pre-mRNA splicing is catalyzed by the spliceosome.U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5'splice site and branch-point sequence. U11 and U12 snRNPs arecomponents of U12-type spliceosome and function as a molecularbridge connecting both ends of the intron. The protein encoded bythis gene contains a RNA recognition motif. It was identified asone of the protein components of U11/U12 snRNPs. This protein andmany other U11/U12 snRNP proteins are highly conserved in organismsknown to contain U12-type introns. These proteins have been shownto be essential for cell viability, suggesting the key roles inU12-type splicing.
Wang, H., et al. Genomics 89(1):59-69(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Will, C.L., et al. RNA 10(6):929-941(2004)
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