|Other Names||Vacuolar protein sorting-associated protein 54, Hepatocellular carcinoma protein 8, Tumor antigen HOM-HCC-8, Tumor antigen SLP-8p, VPS54, HCC8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).|
|Cellular Location||Golgi apparatus, trans-Golgi network|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes for a protein that in yeast forms partof a trimeric vacuolar-protein-sorting complex that is required forretrograde transport of proteins from prevacuoles to the late Golgicompartment. As in yeast, mammalian Vps54 proteins contain acoiled-coil region and dileucine motifs. Alternative splicingresults in multiple transcript variants encoding different isoforms
Perez-Victoria, F.J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(29):12860-12865(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Perez-Victoria, F.J., et al. Mol. Cell. Biol. 29(19):5251-5263(2009)Meisler, M.H., et al. Amyotroph Lateral Scler 9(3):141-148(2008)Perez-Victoria, F.J., et al. Mol. Biol. Cell 19(6):2350-2362(2008)
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