|Other Names||DnaJ homolog subfamily C member 9, DnaJ protein SB73, DNAJC9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear Translocates to the cytoplasm and membrane after heat shock|
|Tissue Location||Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.|
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Provided below are standard protocols that you may find useful for product applications.
DNAJC9 is upregulated at both mRNA and protein levels after various mitogenic and stress stimulations. DNAJC9 is mainly localized in cell nuclei under normal culture conditions, and transported into cytoplasm and plasma membrane upon heat shock stress through a non-classical and lipid-dependent pathway. DNAJC9 can interact with HSP70s and activate the ATPase activity of HSP70s, both of which are dependent on the J domain. Research has indicated that DNAJC9 is a novel cochaperone for HSP70s.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Pan, Z., et al. Neoplasma 57(2):123-128(2010)Han, C., et al. Biochem. Biophys. Res. Commun. 353(2):280-285(2007)Takamura, Y., et al. Biochem. Biophys. Res. Commun. 285(2):387-392(2001)
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