|Other Names||Ras-related protein Rab-11B, GTP-binding protein YPT3, RAB11B, YPT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.|
|Cellular Location||Recycling endosome membrane; Lipid-anchor; Cytoplasmic side Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus|
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Provided below are standard protocols that you may find useful for product applications.
The Ras superfamily of small GTP-binding proteins, whichincludes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (seeMIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508)families, is involved in controlling a diverse set of essentialcellular functions. The Rab family, including RAB11B, appears toplay a critical role in regulating exocytotic and endocytoticpathways (summary by Zhu et al., 1994 [PubMed 7811277]).[suppliedby OMIM].
Agop-Nersesian, C., et al. PLoS Pathog. 6 (7), E1001029 (2010) :Silvis, M.R., et al. Mol. Biol. Cell 20(8):2337-2350(2009)Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)Scapin, S.M., et al. J. Struct. Biol. 154(3):260-268(2006)Khvotchev, M.V., et al. J. Neurosci. 23(33):10531-10539(2003)
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