|Other Names||Ras-related protein Rap-1A, C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, RAP1A, KREV1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.|
|Cellular Location||Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation Localized with RAPGEF2 at cell-cell junctions (By similarity) Colocalized with RAPGEF2 in the perinuclear region.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family ofRAS-related proteins. These proteins share approximately 50% aminoacid identity with the classical RAS proteins and have numerousstructural features in common. The most striking difference betweenRAP proteins and RAS proteins resides in their 61st amino acid:glutamine in RAS is replaced by threonine in RAP proteins. Theproduct of this gene counteracts the mitogenic function of RASbecause it can interact with RAS GAPs and RAF in a competitivemanner. Two transcript variants encoding the same protein have beenidentified for this gene.
Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)Kelly, P., et al. J. Biol. Chem. 285(21):15777-15785(2010)Ahmed, S.M., et al. J. Biol. Chem. 285(9):6538-6551(2010)Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :Sarthy, J., et al. EMBO J. 28(21):3390-3399(2009)
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