|Other Names||Ras GTPase-activating protein 1, GAP, GTPase-activating protein, RasGAP, Ras p21 protein activator, p120GAP, RASA1, GAP, RASA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.|
|Tissue Location||In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).|
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The protein encoded by this gene is located in thecytoplasm and is part of the GAP1 family of GTPase-activatingproteins. The gene product stimulates the GTPase activity of normalRAS p21 but not its oncogenic counterpart. Acting as a suppressorof RAS function, the protein enhances the weak intrinsic GTPaseactivity of RAS proteins resulting in the inactive GDP-bound formof RAS, thereby allowing control of cellular proliferation anddifferentiation. Mutations leading to changes in the binding sitesof either protein are associated with basal cell carcinomas.Alternative splicing results in two isoforms where the shorterisoform, lacking the N-terminal hydrophobic region but retainingthe same activity, appears to be abundantly expressed in placentalbut not adult tissues.
Hemerly, J.P., et al. Eur. J. Endocrinol. 163(5):747-755(2010)Wiemels, J.L., et al. Blood Cells Mol. Dis. 45(3):186-191(2010)Bachas, C., et al. Blood 116(15):2752-2758(2010)Oinuma, I., et al. J. Biol. Chem. 285(36):28200-28209(2010)Anand, S., et al. Nat. Med. 16(8):909-914(2010)
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