|Other Names||Cadherin-19, CDH19, CDH7L2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in many tissues, with the exception of uterus|
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This gene is a type II classical cadherin from thecadherin superfamily and one of three cadherin 7-like genes locatedin a cluster on chromosome 18. The encoded membrane protein is acalcium dependent cell-cell adhesion glycoprotein comprised of fiveextracellular cadherin repeats, a transmembrane region and a highlyconserved cytoplasmic tail. Type II (atypical) cadherins aredefined based on their lack of a HAV cell adhesion recognitionsequence specific to type I cadherins. Since disturbance ofintracellular adhesion is a prerequisite for invasion andmetastasis of tumor cells, cadherins are considered primecandidates for tumor suppressor genes.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kools, P., et al. Genomics 68(3):283-295(2000)Shimoyama, Y., et al. Biochem. J. 349 (PT 1), 159-167 (2000) :Kremmidiotis, G., et al. Genomics 49(3):467-471(1998)
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