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CDH19 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H159 |
|---|---|
| Clone Names | 101008187 |
| Gene ID | 28513 |
|---|---|
| Other Names | Cadherin-19, CDH19, CDH7L2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDH19 |
|---|---|
| Synonyms | CDH7L2 |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in many tissues, with the exception of uterus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a type II classical cadherin from thecadherin superfamily and one of three cadherin 7-like genes locatedin a cluster on chromosome 18. The encoded membrane protein is acalcium dependent cell-cell adhesion glycoprotein comprised of fiveextracellular cadherin repeats, a transmembrane region and a highlyconserved cytoplasmic tail. Type II (atypical) cadherins aredefined based on their lack of a HAV cell adhesion recognitionsequence specific to type I cadherins. Since disturbance ofintracellular adhesion is a prerequisite for invasion andmetastasis of tumor cells, cadherins are considered primecandidates for tumor suppressor genes.
References
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kools, P., et al. Genomics 68(3):283-295(2000)Shimoyama, Y., et al. Biochem. J. 349 (PT 1), 159-167 (2000) :Kremmidiotis, G., et al. Genomics 49(3):467-471(1998)
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