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PON2 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15165
Clone Names 101008142
Peptide ID 101008142
Additional Information
Gene ID 5445
Other Names Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PON2
Function Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Cellular Location Membrane; Peripheral membrane protein
Tissue Location Widely expressed with highest expression in liver, lung, placenta, testis and heart
Research Areas
Citations (0)

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Background

This gene encodes a member of the paraoxonase gene family,which includes three known members located adjacent to each otheron the long arm of chromosome 7. The encoded protein isubiquitously expressed in human tissues, membrane-bound, and mayact as a cellular antioxidant, protecting cells from oxidativestress. Hydrolytic activity against acylhomoserine lactones,important bacterial quorum-sensing mediators, suggests the encodedprotein may also play a role in defense responses to pathogenicbacteria. Mutations in this gene may be associated with vasculardisease and a number of quantitative phenotypes related todiabetes. Alternatively spliced transcript variants encodingdifferent isoforms have been described.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Altenhofer, S., et al. J. Biol. Chem. 285(32):24398-24403(2010)Ticozzi, N., et al. Ann. Neurol. 68(1):102-107(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)Cross, D.S., et al. BMC Genet. 11, 51 (2010) :

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$ 80.00
Cat# BP12952a
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