|Other Names||Matrilin-3, MATN3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.|
|Tissue Location||Expressed only in cartilaginous tissues, such as vertebrae, ribs and shoulders|
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This gene encodes a member of von Willebrand factor Adomain containing protein family. This family of proteins isthought to be involved in the formation of filamentous networks inthe extracellular matrices of various tissues. This proteincontains two von Willebrand factor A domains; it is present in thecartilage extracellular matrix and has a role in the developmentand homeostasis of cartilage and bone. Mutations in this generesult in multiple epiphyseal dysplasia.
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)Otten, C., et al. Hum. Mutat. 31(3):254-263(2010)Klatt, A.R., et al. FEBS Lett. 583(22):3611-3617(2009)Vincourt, J.B., et al. Arthritis Rheum. 58(9):2798-2808(2008)
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