|Other Names||Dendritic cell nuclear protein 1, Dendritic cell nuclear protein-1, Dendritic cell-associated nuclear protein, DCANP1 (HGNC:24459)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds with and transactivates the corticotropin- releasing hormone (CRH) promoter.|
|Cellular Location||Nucleus. Cytoplasm. Note=Particularly on the periphery Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus|
|Tissue Location||Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells. EMBL; AB074498; BAB84585.1; -; mRNA EMBL; AC022092; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC069608; AAH69608.1; -; mRNA EMBL; BC069610; AAH69610.1; -; mRNA EMBL; BC074831; AAH74831.1; -; mRNA EMBL; BC074832; AAH74832.1; -; mRNA CCDS; CCDS4186.1; - PIR; JC7801; JC7801 RefSeq; NP_570900.1; NM_130848.2 UniGene; Hs.152477; - ProteinModelPortal; Q8TF63; - SMR; Q8TF63; - BioGrid; 126768; 1 IntAct; Q8TF63; 2 STRING; 9606.ENSP00000421871; - iPTMnet; Q8TF63; - PhosphoSitePlus; Q8TF63; - BioMuta; DCNP1; - PaxDb; Q8TF63; - PRIDE; Q8TF63; - DNASU; 140947; - Ensembl; ENST00000503143; ENSP00000421871; ENSG00000251380 GeneID; 140947; - KEGG; hsa:140947; - UCSC; uc003lav.3; human CTD; 140947; - DisGeNET; 140947; - GeneCards; DCANP1; - HGNC; HGNC:24459; DCANP1 HPA; HPA048308; - MIM; 609710; gene neXtProt; NX_Q8TF63; - OpenTargets; ENSG00000251380; - PharmGKB; PA142672373; - eggNOG; ENOG410KHFY; Eukaryota eggNOG; ENOG4110RAG; LUCA GeneTree; ENSGT00550000075626; - HOGENOM; HOG000205565; - OMA; SHLALYQ; - OrthoDB; EOG091G0KDV; - BioCyc; ZFISH:G66-33657-MONOMER; - GenomeRNAi; 140947; - PRO; PR:Q8TF63; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000251380; - CleanEx; HS_C5orf20; - Genevisible; Q8TF63; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW 1: Evidence at protein level; Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1 244 Dendritic cell nuclear protein 1 /FTId=PRO_0000229790 COMPBIAS 167 235 Ser-rich VARIANT 75 75 T -> P (in dbSNP:rs1031844) /FTId=VAR_025758 VARIANT 97 97 N -> D (in dbSNP:rs12520809) /FTId=VAR_025759 SEQUENCE 244 AA; 26704 MW; 803125CEFA61B9F8 CRC64; MHYGAATHIQ NSRSHGLETV PGHQRLERGA GGETPEFPGC HSPAPPENFG NELLPLSAPL QGLSEGLYPP GRNKTLPAGV LREGAVQFLH RGLCNSNLSS EASARPSGTQ DELHSSRRKT GQTRREGARK HLVCSFRLYP FTVHTVSPGN SHLALYQVFK AVKLCPSETS FFLSRKSLKS SDPWHPPSLS PNSWNRQAGF RAWSSHLISL SLTCSDSQSR RVSSSQQPPL HSLSSHRRAA HVPE|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene is specifically expressed indendritic cells (DCs), which are potent antigen-presenting cellsinvolved in activating naive T cells to initiate antigen-specificimmune response. The encoded protein is localized mainly in theperinucleus. One of the alleles (A/T) of this gene, that causespremature translation termination at aa 117, has been associatedwith an increased prevalence of major depression in humans.
Zhou, T., et al. Brain 133(10):3069-3079(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Kim, Y., et al. Genes Immun. 8(5):369-378(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Willis-Owen, S.A., et al. Mol. Psychiatry 11(2):121-122(2006)
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