|Other Names||E2F-associated phosphoprotein, EAPP, EAPP, C14orf11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a phosphoprotein that interacts withseveral members of the E2F family of proteins. The proteinlocalizes to the nucleus, and is present throughout the cell cycleexcept during mitosis. It functions to modulate E2F-regulatedtranscription and stimulate proliferation.
Schwarzmayr, L., et al. Int. J. Biochem. Cell Biol. 40(12):2845-2853(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Lim, J., et al. Cell 125(4):801-814(2006)
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