|Other Names||Taste receptor type 2 member 1, T2R1, Taste receptor family B member 7, TRB7, TAS2R1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells|
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This gene encodes a member of a family of candidate tastereceptors that are members of the G protein-coupled receptorsuperfamily and that are specifically expressed by taste receptorcells of the tongue and palate epithelia. This intronless tastereceptor gene encodes a 7-transmembrane receptor protein,functioning as a bitter taste receptor. This gene is mapped tochromosome 5p15, the location of a genetic locus (PROP) thatcontrols the detection of the bitter compound6-n-propyl-2-thiouracil.
Upadhyaya, J., et al. Biochem. Biophys. Res. Commun. 398(2):331-335(2010)Weiss, L.A., et al. Nature 461(7265):802-808(2009)Go, Y., et al. Genetics 170(1):313-326(2005)Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)Zhang, Y., et al. Cell 112(3):293-301(2003)
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