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CHTF18 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8WVB6
Clone Names 100405055
Peptide ID 100405055
Additional Information
Gene ID 63922
Other Names Chromosome transmission fidelity protein 18 homolog, hCTF18, CHL12, CHTF18, C16orf41, CTF18
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHTF18
Synonyms C16orf41, CTF18
Function Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.
Cellular Location Nucleus. Note=Associates with chromatin during S phase
Research Areas
Citations (0)

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CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203)are components of an alternative replication factor C (RFC) (seeMIM 600404) complex that loads PCNA (MIM 176740) onto DNA during Sphase of the cell cycle (Merkle et al., 2003 [PubMed 12766176];Bermudez et al., 2003 [PubMed 12930902]).


Murakami, T., et al. J. Biol. Chem. 285(45):34608-34615(2010)Farina, A., et al. J. Biol. Chem. 283(30):20925-20936(2008)Shiomi, Y., et al. J. Biol. Chem. 282(29):20906-20914(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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$ 80.00
Cat# BP12986b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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