|Other Names||Ras GTPase-activating protein nGAP, RAS protein activator-like 2, RASAL2, NGAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains the GAP-relateddomain (GRD), a characteristic domain of GTPase-activating proteins(GAPs). GAPs function as activators of Ras superfamily of smallGTPases. The protein encoded by this gene is able to complement thedefective RasGAP function in a yeast system. Two alternativelyspliced transcript variants of this gene encoding distinct isoformshave been reported.
Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010)Shibui, T., et al. Biotechnol. Lett. 30(12):2037-2043(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Noto, S., et al. FEBS Lett. 441(1):127-131(1998)
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