|Other Names||Cation channel sperm-associated protein 1, CatSper1, hCatSper, CATSPER1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.|
|Cellular Location||Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail|
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Provided below are standard protocols that you may find useful for product applications.
Calcium ions play a primary role in the regulation ofsperm motility. This gene belongs to a family of putative cationchannels that are specific to spermatozoa and localize to theflagellum. The protein family features a single repeat with sixmembrane-spanning segments and a predicted calcium-selective poreregion.
Li, H., et al. Fertil. Steril. 92(3):1141-1146(2009)Avenarius, M.R., et al. Am. J. Hum. Genet. 84(4):505-510(2009)Zhang, D., et al. J. Biol. Chem. 281(31):22332-22341(2006)Li, H.G., et al. Asian J. Androl. 8(3):301-306(2006)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)
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