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CATSPER1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NEC5 |
|---|---|
| Clone Names | 100405172 |
| Gene ID | 117144 |
|---|---|
| Other Names | Cation channel sperm-associated protein 1, CatSper1, hCatSper, CATSPER1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CATSPER1 |
|---|---|
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. |
| Cellular Location | Cell projection, cilium, flagellum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91ZR5}. Note=Specifically located in the principal piece of the sperm tail. |
| Tissue Location | Testis-specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium ions play a primary role in the regulation ofsperm motility. This gene belongs to a family of putative cationchannels that are specific to spermatozoa and localize to theflagellum. The protein family features a single repeat with sixmembrane-spanning segments and a predicted calcium-selective poreregion.
References
Li, H., et al. Fertil. Steril. 92(3):1141-1146(2009)Avenarius, M.R., et al. Am. J. Hum. Genet. 84(4):505-510(2009)Zhang, D., et al. J. Biol. Chem. 281(31):22332-22341(2006)Li, H.G., et al. Asian J. Androl. 8(3):301-306(2006)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)
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