|Other Names||Hemoglobin subunit theta-1, Hemoglobin theta-1 chain, Theta-1-globin, HBQ1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Theta-globin mRNA is found in human fetal erythroid tissuebut not in adult erythroid or other nonerythroid tissue. Thetheta-1 gene may be expressed very early in embryonic life, perhapssometime before 5 weeks. Theta-1 is a member of the humanalpha-globin gene cluster that involves five functional genes andtwo pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu- pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'.Research supports a transcriptionally active role for the gene anda functional role for the peptide in specific cells, possibly thoseof early erythroid tissue.
De Gobbi, M., et al. Science 312(5777):1215-1217(2006)Patrinos, G.P., et al. Hum. Mutat. 26(5):399-412(2005)Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)Giardina, B., et al. Crit. Rev. Biochem. Mol. Biol. 30(3):165-196(1995)Kim, J.H., et al. Nucleic Acids Res. 17(14):5687-5700(1989)
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