|Other Names||GPI mannosyltransferase 2, 241-, GPI mannosyltransferase II, GPI-MT-II, Phosphatidylinositol-glycan biosynthesis class V protein, PIG-V, PIGV|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Glycosylphosphatidylinositol (GPI) is a complex glycolipidthat anchors many proteins to the cell surface. The biosyntheticpathway of GPI is mediated by sequential addition of sugars andother components to phosphatidylinositol. PIGV adds the secondmannose to the GPI core (Kang et al., 2005 [PubMed15623507]).
Krawitz, P.M., et al. Nat. Genet. 42(10):827-829(2010)Kang, J.Y., et al. J. Biol. Chem. 280(10):9489-9497(2005)Fabre, A.L., et al. FEBS J. 272(5):1160-1168(2005)Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
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