|Other Names||Semaphorin-4C, SEMA4C, KIAA1739, SEMAI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein|
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Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Wu, H., et al. Eur. J. Cell Biol. 86(6):331-344(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Inagaki, S., et al. J. Biol. Chem. 276(12):9174-9181(2001)Ohoka, Y., et al. Biochem. Biophys. Res. Commun. 280(1):237-243(2001)Wang, L.H., et al. J. Biol. Chem. 274(20):14137-14146(1999)
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