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TMM70 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BUB7
Clone Names 91201111
Additional Information
Gene ID 54968
Other Names Transmembrane protein 70, mitochondrial, TMEM70
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM70 (HGNC:26050)
Function Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane
Tissue Location Lower expressed in the heart than in the liver (at protein level).
Research Areas
Citations (0)
citation

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Background

This gene likely encodes a mitochondrial membrane protein.The encoded protein may play a role in biogenesis of mitochondrialATP synthase. Mutations in this gene have been associated withneonatal mitochondrial encephalocardiomyopathy due to ATP synthasedeficiency. Alternatively spliced transcript variants have beendescribed.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Karasik, D., et al. J. Bone Miner. Res. 25(7):1555-1563(2010)Honzik, T., et al. Arch. Dis. Child. 95(4):296-301(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 277.78
Cat# BP13011b
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