TMM70 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BUB7 |
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Clone Names | 91201111 |
Gene ID | 54968 |
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Other Names | Transmembrane protein 70, mitochondrial, TMEM70 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMEM70 (HGNC:26050) |
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Function | Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929). |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane |
Tissue Location | Lower expressed in the heart than in the liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene likely encodes a mitochondrial membrane protein.The encoded protein may play a role in biogenesis of mitochondrialATP synthase. Mutations in this gene have been associated withneonatal mitochondrial encephalocardiomyopathy due to ATP synthasedeficiency. Alternatively spliced transcript variants have beendescribed.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Karasik, D., et al. J. Bone Miner. Res. 25(7):1555-1563(2010)Honzik, T., et al. Arch. Dis. Child. 95(4):296-301(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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