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CTSR3 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q86XQ3
Clone Names 91208054
Peptide ID 91208054
Additional Information
Gene ID 347732
Other Names Cation channel sperm-associated protein 3, CatSper3, Ca(v)-like protein, One-repeat calcium channel-like protein, CATSPER3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Cellular Location Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail
Tissue Location Testis-specific.
Research Areas
Citations (0)

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Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization (By similarity).


Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Qi, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(4):1219-1223(2007)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)Lobley, A., et al. Reprod. Biol. Endocrinol. 1, 53 (2003) :Arias, J.M., et al. Biochem. Biophys. Res. Commun. 303(1):31-36(2003)

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$ 80.00
Cat# BP13012b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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