|Other Names||Cation channel sperm-associated protein 3, CatSper3, Ca(v)-like protein, One-repeat calcium channel-like protein, CATSPER3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.|
|Cellular Location||Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail|
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Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization (By similarity).
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Qi, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(4):1219-1223(2007)Clapham, D.E., et al. Pharmacol. Rev. 57(4):451-454(2005)Lobley, A., et al. Reprod. Biol. Endocrinol. 1, 53 (2003) :Arias, J.M., et al. Biochem. Biophys. Res. Commun. 303(1):31-36(2003)
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