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Bak Antibody (BH3 Domain Specific) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q16611
Clone Names 2011001
Peptide ID 2011001
Additional Information
Gene ID 578
Other Names Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7, BAK1, BAK, BCL2L7, CDN1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1301a was selected from the region of human Bak BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAK1
Synonyms BAK, BCL2L7, CDN1
Function In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Cellular Location Mitochondrion membrane; Single-pass membrane protein
Tissue Location Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
Research Areas
Citations (0)

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BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.


Cartron, P.F., et al., Mol. Cell. Biol. 23(13):4701-4712 (2003).Mikhailov, V., et al., J. Biol. Chem. 278(7):5367-5376 (2003).Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).Bellosillo, B., et al., Blood 100(5):1810-1816 (2002).Grutkoski, P.S., et al., Shock 17(1):47-54 (2002).

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$ 80.00
Cat# BP1301a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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