|Other Names||Potassium voltage-gated channel subfamily D member 1, Voltage-gated potassium channel subunit Kv41, KCND1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell projection, dendrite|
|Tissue Location||Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.|
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Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. Four sequence-relatedpotassium channel genes - shaker, shaw, shab, and shal - have beenidentified in Drosophila, and each has been shown to have humanhomolog(s). This gene encodes a member of the potassium channel,voltage-gated, shal-related subfamily, members of which formvoltage-activated A-type potassium ion channels and are prominentin the repolarization phase of the action potential. This gene isexpressed at moderate levels in all tissues analyzed, with lowerlevels in skeletal muscle.
Jang, S.H., et al. Biochem. Biophys. Res. Commun. 384(2):180-186(2009)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Jerng, H.H., et al. Biophys. J. 87(4):2380-2396(2004)Nakamura, T.Y., et al. FEBS Lett. 499(3):205-209(2001)Isbrandt, D., et al. Genomics 64(2):144-154(2000)
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