|Other Names||Ankyrin repeat domain-containing protein 6, Diversin, ANKRD6, KIAA0957|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.|
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Provided below are standard protocols that you may find useful for product applications.
ANKRD6 recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals (By similarity).
Haribaskar, R., et al. Biochem. Biophys. Res. Commun. 387(1):212-217(2009)Miyasaka, K.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(27):11274-11279(2007)Schwarz-Romond, T., et al. Genes Dev. 16(16):2073-2084(2002)Tissir, F., et al. Dev. Dyn. 224(4):465-469(2002)
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