|Other Names||Stearoyl-CoA desaturase 5, Acyl-CoA-desaturase 4, HSCD5, Stearoyl-CoA 9-desaturase, SCD5, ACOD4, SCD4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.|
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Stearoyl-CoA desaturase (SCD; EC 22.214.171.124) is an integralmembrane protein of the endoplasmic reticulum that catalyzes theformation of monounsaturated fatty acids from saturated fattyacids. SCD may be a key regulator of energy metabolism with a rolein obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4,have been identified in mouse. In contrast, only 2 SCD isoforms,SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1shares about 85% amino acid identity with all 4 mouse SCD isoforms,as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limitedhomology with the rodent SCDs and appears to be unique to primates(Wang et al., 2005 [PubMed 15907797]).
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lengi, A.J., et al. Lipids 42(6):499-508(2007)
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