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SCD5 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86SK9
Clone Names 100406176
Peptide ID 100406176
Additional Information
Gene ID 79966
Other Names Stearoyl-CoA desaturase 5, Acyl-CoA-desaturase 4, HSCD5, Stearoyl-CoA 9-desaturase, SCD5, ACOD4, SCD4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SCD5
Synonyms ACOD4, SCD2 {ECO:0000303|PubMed:15610069
Function Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.
Research Areas
Citations (0)

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Background

Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integralmembrane protein of the endoplasmic reticulum that catalyzes theformation of monounsaturated fatty acids from saturated fattyacids. SCD may be a key regulator of energy metabolism with a rolein obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4,have been identified in mouse. In contrast, only 2 SCD isoforms,SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1shares about 85% amino acid identity with all 4 mouse SCD isoforms,as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limitedhomology with the rodent SCDs and appears to be unique to primates(Wang et al., 2005 [PubMed 15907797]).

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lengi, A.J., et al. Lipids 42(6):499-508(2007)

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$ 80.00
Cat# BP13043c
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