|Other Names||Kremen protein 2, Dickkopf receptor 2, Kringle domain-containing transmembrane protein 2, Kringle-containing protein marking the eye and the nose, KREMEN2, KRM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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This gene encodes a high-affinity dickkopf homolog 1(DKK1) transmembrane receptor that functionally cooperates withDKK1 to block wingless (WNT)/beta-catenin signaling. The encodedprotein forms a ternary membrane complex with DKK1 and the WNTreceptor lipoprotein receptor-related protein 6 (LRP6), and inducesrapid endocytosis and removal of LRP6 from the plasma membrane. Itcontains extracellular kringle, WSC, and CUB domains. Alternativelyspliced transcript variants encoding distinct isoforms have beenobserved for this gene.
Mao, B., et al. Nature 417(6889):664-667(2002)
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