|Other Names||Myeloperoxidase, MPO, Myeloperoxidase, 89 kDa myeloperoxidase, 84 kDa myeloperoxidase, Myeloperoxidase light chain, Myeloperoxidase heavy chain, MPO|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.|
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Myeloperoxidase (MPO) is a heme protein synthesized duringmyeloid differentiation that constitutes the major component ofneutrophil azurophilic granules. Produced as a single chainprecursor, myeloperoxidase is subsequently cleaved into a light andheavy chain. The mature myeloperoxidase is a tetramer composed of2 light chains and 2 heavy chains. This enzyme produces hypohalousacids central to the microbicidal activity of netrophils. [providedby RefSeq].
Banerjee, M., et al. Toxicol. Appl. Pharmacol. 249(1):47-54(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Nahon, P., et al. Antioxid. Redox Signal. (2010) In press :Wang, Y., et al. J. Huazhong Univ. Sci. Technol. Med. Sci. 30(4):437-442(2010)Hua, F., et al. Zhongguo Fei Ai Za Zhi 13(2):122-127(2010)
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