|Other Names||B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A, IGA, MB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.|
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Provided below are standard protocols that you may find useful for product applications.
The B lymphocyte antigen receptor is a multimeric complexthat includes the antigen-specific component, surfaceimmunoglobulin (Ig). Surface Ig non-covalently associates with twoother proteins, Ig-alpha and Ig-beta, which are necessary forexpression and function of the B-cell antigen receptor. This geneencodes the Ig-alpha protein of the B-cell antigen component.Alternatively spliced transcript variants encoding differentisoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Hoeller, S., et al. Histopathology 56(2):217-228(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Tanaka, T., et al. Pathol. Int. 59(11):804-808(2009)
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