|Other Names||CD99 antigen, E2 antigen, Protein MIC2, T-cell surface glycoprotein E2, CD99, CD99, MIC2, MIC2X, MIC2Y|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MIC2, MIC2X, MIC2Y|
|Function||Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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The protein encoded by this gene is a cell surfaceglycoprotein involved in leukocyte migration, T-cell adhesion,ganglioside GM1 and transmembrane protein transport, and T-celldeath by a caspase-independent pathway. In addition, the encodedprotein may have the ability to rearrange the actin cytoskeletonand may also act as an oncosuppressor in osteosarcoma. CyclophilinA binds to CD99 and may act as a signaling regulator of CD99. Thisgene is found in the pseudoautosomal region of chromosomes X and Yand escapes X-chromosome inactivation. Two transcript variantsencoding different isoforms have been found for this gene.
Husak, Z., et al. J. Leukoc. Biol. 88(2):405-412(2010)Kanner, W.A., et al. J. Cutan. Pathol. 37(7):744-750(2010)Duncan, L.M., et al. J. Immunol. 184(12):6978-6985(2010)Rocchi, A., et al. J. Clin. Invest. 120(3):668-680(2010)Yoshino, N., et al. Ann Thorac Cardiovasc Surg 15(5):324-327(2009)
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