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HIST1H2AB Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P04908
Clone Names 110111003
Additional Information
Gene ID 3012;8335
Other Names Histone H2A type 1-B/E, Histone H2A2, Histone H2A/a, Histone H2A/m, HIST1H2AB, H2AFM
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H2AC4 (HGNC:4734)
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Research Areas
Citations (0)
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Background

Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. This structure consists of approximately 146 bp of DNAwrapped around a nucleosome, an octamer composed of pairs of eachof the four core histones (H2A, H2B, H3, and H4). The chromatinfiber is further compacted through the interaction of a linkerhistone, H1, with the DNA between the nucleosomes to form higherorder chromatin structures. This gene is intronless and encodes amember of the histone H2A family. Transcripts from this gene lackpolyA tails; instead, they contain a palindromic terminationelement. This gene is found in the large histone gene cluster onchromosome 6p22-p21.3.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006)Cao, R., et al. Mol. Cell 20(6):845-854(2005)Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)

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$ 277.78
Cat# BP13062a
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