|Other Names||Glycine N-acyltransferase, Acyl-CoA:glycine N-acyltransferase, AAc, Aralkyl acyl-CoA N-acyltransferase, Aralkyl acyl-CoA:amino acid N-acyltransferase, Benzoyl-coenzyme A:glycine N-acyltransferase, Glycine N-benzoyltransferase, HRP-1(CLP), GLYAT, ACGNAT, CAT, GAT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACGNAT, CAT, GAT|
|Function||Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.|
|Tissue Location||Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers.|
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Provided below are standard protocols that you may find useful for product applications.
The glycine-N-acyltransferase protein conjugates glycinewith acyl-CoA substrates in the mitochondria. The protein isthought to be important in the detoxification of endogenous andxenobiotic acyl-CoA's. Two transcript variants encoding differentisoforms have been found for this gene.
Yamamoto, A., et al. Drug Metab. Pharmacokinet. 24(1):114-117(2009)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)van der Westhuizen, F.H., et al. J. Biochem. Mol. Toxicol. 14(2):102-109(2000)Mawal, Y., et al. J. Pediatr. 130(6):1003-1007(1997)Merkler, D.J., et al. Arch. Biochem. Biophys. 330(2):430-434(1996)
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