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GLYAT Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6IB77 |
|---|---|
| Clone Names | 110111024 |
| Gene ID | 10249 |
|---|---|
| Other Names | Glycine N-acyltransferase, Acyl-CoA:glycine N-acyltransferase, AAc, Aralkyl acyl-CoA N-acyltransferase, Aralkyl acyl-CoA:amino acid N-acyltransferase, Benzoyl-coenzyme A:glycine N-acyltransferase, Glycine N-benzoyltransferase, HRP-1(CLP), GLYAT, ACGNAT, CAT, GAT |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GLYAT |
|---|---|
| Synonyms | ACGNAT, CAT, GAT |
| Function | Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N- acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Predominantly expressed in liver (at protein level) and kidney. Down-regulated in hepatocellular carcinoma and other liver cancers. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The glycine-N-acyltransferase protein conjugates glycinewith acyl-CoA substrates in the mitochondria. The protein isthought to be important in the detoxification of endogenous andxenobiotic acyl-CoA's. Two transcript variants encoding differentisoforms have been found for this gene.
References
Yamamoto, A., et al. Drug Metab. Pharmacokinet. 24(1):114-117(2009)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)van der Westhuizen, F.H., et al. J. Biochem. Mol. Toxicol. 14(2):102-109(2000)Mawal, Y., et al. J. Pediatr. 130(6):1003-1007(1997)Merkler, D.J., et al. Arch. Biochem. Biophys. 330(2):430-434(1996)
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