|Other Names||Sodium-dependent neutral amino acid transporter B(0)AT3, Sodium- and chloride-dependent transporter XTRP2, Solute carrier family 6 member 18, System B(0) neutral amino acid transporter AT3, SLC6A18, XTRP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a sodium and chloride-dependent neutral amino acid transporter.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Abundantly expressed in kidney, but not in intestine.|
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Provided below are standard protocols that you may find useful for product applications.
The SLC6 family of proteins, which includes SLC6A18, actas specific transporters for neurotransmitters, amino acids, andosmolytes like betaine, taurine, and creatine. SLC6 proteins aresodium cotransporters that derive the energy for solute transportfrom the electrochemical gradient for sodium ions (Hoglund et al.,2005 [PubMed 16125675]).
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Singer, D., et al. J. Biol. Chem. 284(30):19953-19960(2009)Yoon, Y.H., et al. DNA Cell Biol. 27(10):559-567(2008)Broer, S. Physiol. Rev. 88(1):249-286(2008)Eslami, B., et al. Tohoku J. Exp. Med. 208(1):25-31(2006)
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