|Other Names||Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519, GNLY, LAG2, NKG5, TLA519|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAG2, NKG5, TLA519|
|Function||Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.|
|Cellular Location||Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation|
|Tissue Location||Expressed in natural killer and T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a member of the saposin-likeprotein (SAPLIP) family and is located in the cytotoxic granules ofT cells, which are released upon antigen stimulation. This proteinis present in cytotoxic granules of cytotoxic T lymphocytes andnatural killer cells, and it has antimicrobial activity against M.tuberculosis and other organisms. Alternatively spliced transcriptvariants encoding different isoforms have been identified.
Xing, J., et al. J. Immunol. 185(9):5074-5081(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yang, C., et al. Int. J. Tuberc. Lung Dis. 13(11):1360-1366(2009)Hogg, A.E., et al. J. Leukoc. Biol. 86(5):1191-1203(2009)
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