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GNLY Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P22749 |
|---|---|
| Clone Names | 101008298 |
| Gene ID | 10578 |
|---|---|
| Other Names | Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519, GNLY, LAG2, NKG5, TLA519 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNLY |
|---|---|
| Synonyms | LAG2, NKG5, TLA519 |
| Function | Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. |
| Cellular Location | Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation |
| Tissue Location | Expressed in natural killer and T-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is a member of the saposin-likeprotein (SAPLIP) family and is located in the cytotoxic granules ofT cells, which are released upon antigen stimulation. This proteinis present in cytotoxic granules of cytotoxic T lymphocytes andnatural killer cells, and it has antimicrobial activity against M.tuberculosis and other organisms. Alternatively spliced transcriptvariants encoding different isoforms have been identified.
References
Xing, J., et al. J. Immunol. 185(9):5074-5081(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yang, C., et al. Int. J. Tuberc. Lung Dis. 13(11):1360-1366(2009)Hogg, A.E., et al. J. Leukoc. Biol. 86(5):1191-1203(2009)
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