Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
WDR12 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9GZL7 |
|---|---|
| Clone Names | 100324263 |
| Gene ID | 55759 |
|---|---|
| Other Names | Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}, WD repeat-containing protein 12 {ECO:0000255|HAMAP-Rule:MF_03029}, WDR12 {ECO:0000255|HAMAP-Rule:MF_03029} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | WDR12 {ECO:0000255|HAMAP-Rule:MF_03029} |
|---|---|
| Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
| Cellular Location | Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03029, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:26601951}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This protein ishighly similar to the mouse WD repeat domain 12 protein at theamino acid level. The protein encoded by this gene is a componentof a nucleolar protein complex that affects maturation of the largeribosomal subunit.
References
Kathiresan, S., et al. Nat. Genet. 41(3):334-341(2009)Rohrmoser, M., et al. Mol. Cell. Biol. 27(10):3682-3694(2007)Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)Grimm, T., et al. Nucleic Acids Res. 34(10):3030-3043(2006)Holzel, M., et al. J. Cell Biol. 170(3):367-378(2005)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
