|Other Names||Erlin-1, Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, SPFH domain-containing protein 1, ERLIN1, C10orf69, KE04, KEO4, SPFH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C10orf69, KE04, KEO4, SPFH1|
|Function||Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane|
|Tissue Location||Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine|
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Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :Wang, Y., et al. Biochim. Biophys. Acta 1793(11):1710-1718(2009)Pearce, M.M., et al. J. Biol. Chem. 284(16):10433-10445(2009)Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
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