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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Bid Antibody (BH3 Domain Specific) Blocking peptide   

Bid Antibody (BH3 Domain Specific) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P55957
Clone Names 2011009
Peptide ID 2011009
Additional Information
Gene ID 637
Other Names BH3-interacting domain death agonist, p22 BID, BID, BH3-interacting domain death agonist p15, p15 BID, BH3-interacting domain death agonist p13, p13 BID, BH3-interacting domain death agonist p11, p11 BID, BID
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1307a was selected from the region of human Bid BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BID
Function The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Cellular Location Cytoplasm. Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. Isoform 3: Cytoplasm.
Tissue Location Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level) Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
Research Areas
Citations (0)

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Bid is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release.


Wang, X., et al., J. Biol. Chem. 278(31):29184-29191 (2003).Cartron, P.F., et al., Mol. Cell. Biol. 23(13):4701-4712 (2003).Fischer, B., et al., Biochem. Biophys. Res. Commun. 306(2):516-522 (2003).Degli Esposti, M., et al., J. Biol. Chem. 278(18):15749-15757 (2003).Kuwana, T., et al., Cell 111(3):331-342 (2002).

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$ 80.00
Cat# BP1307a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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