|Other Names||Anion exchange transporter, Solute carrier family 26 member 7, SLC26A7 (HGNC:14467)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion.|
|Cellular Location||Recycling endosome membrane; Multi-pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion|
|Tissue Location||Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts|
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This gene is one member of a family of sulfate/aniontransporter genes. Family members are well conserved in theirgenomic (number and size of exons) and protein (aa length amongspecies) structures yet have markedly different tissue expressionpatterns. This gene has abundant and specific expression in thekidney. Splice variants that use both alternate transcriptioninitiation and polyadenylation sites have been described for thisgene.
Xu, J., et al. J. Am. Soc. Nephrol. 17(4):956-967(2006)Kujala, M., et al. Nephron Exp. Nephrol. 101 (2), E50-E58 (2005) :Barone, S., et al. J. Am. Soc. Nephrol. 15(8):2002-2011(2004)Petrovic, S., et al. Am. J. Physiol. Renal Physiol. 286 (1), F161-F169 (2004) :Petrovic, S., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 284 (6), G1093-G1103 (2003) :
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