|Other Names||CUGBP Elav-like family member 3, CELF-3, Bruno-like protein 1, CAG repeat protein 4, CUG-BP- and ETR-3-like factor 3, ELAV-type RNA-binding protein 1, ETR-1, Expanded repeat domain protein CAG/CTG 4, RNA-binding protein BRUNOL-1, Trinucleotide repeat-containing gene 4 protein, CELF3, BRUNOL1, CAGH4, ERDA4, TNRC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BRUNOL1, CAGH4, ERDA4, TNRC4|
|Function||RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the CELF/BRUNOL protein family contain twoN-terminal RNA recognition motif (RRM) domains, one C-terminal RRMdomain, and a divergent segment of 160-230 aa between the secondand third RRM domains. Members of this protein family regulatepre-mRNA alternative splicing and may also be involved in mRNAediting, and translation. Multiple alternatively spliced transcriptvariants encoding different isoforms have been identified in thisgene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Chapple, J.P., et al. Hum. Mol. Genet. 16(22):2760-2769(2007)Ladd, A.N., et al. Mol. Cell. Biol. 21(4):1285-1296(2001)Good, P.J., et al. J. Biol. Chem. 275(37):28583-28592(2000)
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