|Other Names||Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endothelins are endothelium-derived vasoconstrictor peptides.|
|Tissue Location||Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theendothelin family. Endothelins are endothelium-derived vasoactivepeptides involved in a variety of biological functions. The activeform of this protein is a 21 amino acid peptide processed from theprecursor protein. The active peptide is a ligand for endothelinreceptor type B (EDNRB). The interaction of this endothelin withEDNRB is essential for development of neural crest-derived celllineages, such as melanocytes and enteric neurons. Mutations inthis gene and EDNRB have been associated with Hirschsprung disease(HSCR) and Waardenburg syndrome (WS), which are congenitaldisorders involving neural crest-derived cells. Four alternativelyspliced transcript variants encoding three distinct isoforms havebeen observed.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Darrah, R., et al. Physiol. Genomics 41(1):71-77(2010)Sanchez-Mejias, A., et al. Genet. Med. 12(1):39-43(2010)Broasca, V., et al. Rom J Morphol Embryol 51(2):283-288(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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