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FAM35A Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86V20 |
|---|---|
| Clone Names | 81006144 |
| Gene ID | 54537 |
|---|---|
| Other Names | Protein FAM35A, FAM35A |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13091a was selected from the N-term region of FAM35A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SHLD2 {ECO:0000303|PubMed:29656893, ECO:0000312|HGNC:HGNC:28773} |
|---|---|
| Function | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). |
| Cellular Location | Nucleus. Chromosome. Note=Localizes to nuclear foci in response to DNA damage. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Deloukas, P., et al. Nature 429(6990):375-381(2004)
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