HINT3 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NQE9 |
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Clone Names | 91201207 |
Gene ID | 135114 |
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Other Names | Histidine triad nucleotide-binding protein 3, HINT-3, 3---, HINT3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13096a was selected from the N-term region of HINT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HINT3 |
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Function | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:17870088). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N- alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase (PubMed:17870088). Hydrolyzes 3-indolepropionic acyl-adenylate and fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:17870088). |
Cellular Location | Cytoplasm. Nucleus. Note=Localized as aggregates in the cytoplasm and the nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histidine triad proteins, such as HINT3, are nucleotidehydrolases and transferases that act on the alpha-phosphate ofribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied byOMIM].
References
Chou, T.F., et al. J. Mol. Biol. 373(4):978-989(2007)Brenner, C. Biochemistry 41(29):9003-9014(2002)Bieganowski, P., et al. J. Biol. Chem. 277(13):10852-10860(2002)
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