|Other Names||Syntabulin, Golgi-localized syntaphilin-related protein, Syntaxin-1-binding protein, SYBU, GOLSYN, KIAA1472|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13098a was selected from the N-term region of GOLSYN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.|
|Cellular Location||Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes Isoform 4: Golgi apparatus membrane; Single- pass membrane protein|
|Tissue Location||Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
Syntabulin/GOLSYN is part of a kinesin motor-adaptorcomplex that is critical for the anterograde axonal transport ofactive zone components and contributes to activity-dependentpresynaptic assembly during neuronal development (Cai et al., 2007[PubMed 17611281]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cai, Q., et al. J. Neurosci. 27(27):7284-7296(2007)Funakoshi, E., et al. Neurosci. Lett. 403(3):244-249(2006)Cai, Q., et al. J. Cell Biol. 170(6):959-969(2005)Funakoshi, E., et al. Gene 344, 259-271 (2005) :
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