|Other Names||Dexamethasone-induced Ras-related protein 1, Activator of G-protein signaling 1, RASD1, AGS1, DEXRAS1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13102b was selected from the C-term region of RASD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus|
|Tissue Location||Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.|
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This gene encodes a Ras-related protein that is stimulatedby dexamethasone. The exact function of this gene is unknown, butit may play a role in dexamethasone-induced alterations in cellmorphology, growth and cell-extracellular matrix interactions. Inaddition, studies of a similar rat protein suggest that itfunctions as as a novel physiologic nitric oxide (NO) effector. Thegene product belongs to the Ras superfamily of small GTPases.
Nojima, M., et al. Clin. Cancer Res. 15(13):4356-4364(2009)Lau, K.F., et al. J. Biol. Chem. 283(50):34728-34737(2008)Attarzadeh-Yazdi, G., et al. Neurochem. Res. 33(4):609-613(2008)Cheng, H.Y., et al. J. Neurosci. 26(50):12984-12995(2006)Nguyen, C.H., et al. Mol. Pharmacol. 69(5):1763-1771(2006)
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