|Other Names||Bcl-2-related ovarian killer protein, hBOK, Bcl-2-like protein 9, Bcl2-L-9, BOK, BCL2L9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1310a was selected from the region of human Bok BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces apoptosis in a manner dependent on BAX and BAK.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=The transmembrane domain is necessary and sufficient for Golgi and ER targeting|
|Tissue Location||Expressed in brain, liver, appendix and lymphoid tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Bok belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.
Hsu, S.Y., et al., Proc. Natl. Acad. Sci. U.S.A. 94(23):12401-12406 (1997).Zhang, H., et al., FEBS Lett. 480 (2-3), 311-313 (2000).
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