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GRIK3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13003 |
|---|---|
| Clone Names | 100318114 |
| Gene ID | 2899 |
|---|---|
| Other Names | Glutamate receptor ionotropic, kainate 3, GluK3, Excitatory amino acid receptor 5, EAA5, Glutamate receptor 7, GluR-7, GluR7, GRIK3, GLUR7 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13113a was selected from the N-term region of GRIK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GRIK3 |
|---|---|
| Synonyms | GLUR7 |
| Function | Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glutamate receptors are the predominant excitatoryneurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. This geneproduct belongs to the kainate family of glutamate receptors, whichare composed of four subunits and function as ligand-activated ionchannels. It is not certain if the subunit encoded by this gene issubject to RNA editing as the other 2 family members (GRIK1 andGRIK2). A Ser310Ala polymorphism has been associated withschizophrenia, and there are conflicting reports of its associationwith the pathogenesis of delirium tremens in alcoholics. [providedby RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Luciano, M., et al. Behav. Genet. 40(4):518-532(2010)Kilic, G., et al. Psychiatry Res 175 (1-2), 43-46 (2010) :Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)Ahmad, Y., et al. World J. Biol. Psychiatry 10(4):330-333(2009)
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