|Other Names||Glutamate receptor ionotropic, kainate 3, GluK3, Excitatory amino acid receptor 5, EAA5, Glutamate receptor 7, GluR-7, GluR7, GRIK3, GLUR7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13113a was selected from the N-term region of GRIK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Glutamate receptors are the predominant excitatoryneurotransmitter receptors in the mammalian brain and are activatedin a variety of normal neurophysiologic processes. This geneproduct belongs to the kainate family of glutamate receptors, whichare composed of four subunits and function as ligand-activated ionchannels. It is not certain if the subunit encoded by this gene issubject to RNA editing as the other 2 family members (GRIK1 andGRIK2). A Ser310Ala polymorphism has been associated withschizophrenia, and there are conflicting reports of its associationwith the pathogenesis of delirium tremens in alcoholics. [providedby RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Luciano, M., et al. Behav. Genet. 40(4):518-532(2010)Kilic, G., et al. Psychiatry Res 175 (1-2), 43-46 (2010) :Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)Ahmad, Y., et al. World J. Biol. Psychiatry 10(4):330-333(2009)
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