|Other Names||Vesicular glutamate transporter 1, VGluT1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 7, SLC17A7, BNPI, VGLUT1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13120b was selected from the C-term region of SLC17A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome|
|Tissue Location||Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a vesicle-bound,sodium-dependent phosphate transporter that is specificallyexpressed in the neuron-rich regions of the brain. It ispreferentially associated with the membranes of synaptic vesiclesand functions in glutamate transport. The protein shares 82%identity with the differentiation-associated Na-dependent inorganicphosphate cotransporter and they appear to form a distinct classwithin the Na+/Pi cotransporter family.
Shen, Y.C., et al. Schizophr. Res. 115 (2-3), 254-260 (2009) :Uezato, A., et al. Bipolar Disord 11(7):711-725(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Oni-Orisan, A., et al. Biol. Psychiatry 63(8):766-775(2008)
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