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SLC17A7 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
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- BACKGROUND
| Primary Accession | Q9P2U7 |
|---|---|
| Clone Names | 100324060 |
| Gene ID | 57030 |
|---|---|
| Other Names | Vesicular glutamate transporter 1, VGluT1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 7, SLC17A7, BNPI, VGLUT1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13120b was selected from the C-term region of SLC17A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC17A7 (HGNC:16704) |
|---|---|
| Function | Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q3TXX4}. Cell membrane; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:Q3TXX4} |
| Tissue Location | Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a vesicle-bound,sodium-dependent phosphate transporter that is specificallyexpressed in the neuron-rich regions of the brain. It ispreferentially associated with the membranes of synaptic vesiclesand functions in glutamate transport. The protein shares 82%identity with the differentiation-associated Na-dependent inorganicphosphate cotransporter and they appear to form a distinct classwithin the Na+/Pi cotransporter family.
References
Shen, Y.C., et al. Schizophr. Res. 115 (2-3), 254-260 (2009) :Uezato, A., et al. Bipolar Disord 11(7):711-725(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Oni-Orisan, A., et al. Biol. Psychiatry 63(8):766-775(2008)
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