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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9P2U7 |
|---|---|
| Clone Names | 100324060 |
| Peptide ID | 100324060 |
| Gene ID | 57030 |
|---|---|
| Other Names | Vesicular glutamate transporter 1, VGluT1, Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 7, SLC17A7, BNPI, VGLUT1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13120b was selected from the C-term region of SLC17A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC17A7 |
|---|---|
| Synonyms | BNPI, VGLUT1 |
| Function | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q3TXX4}. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q3TXX4} |
| Tissue Location | Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a vesicle-bound,sodium-dependent phosphate transporter that is specificallyexpressed in the neuron-rich regions of the brain. It ispreferentially associated with the membranes of synaptic vesiclesand functions in glutamate transport. The protein shares 82%identity with the differentiation-associated Na-dependent inorganicphosphate cotransporter and they appear to form a distinct classwithin the Na+/Pi cotransporter family.
References
Shen, Y.C., et al. Schizophr. Res. 115 (2-3), 254-260 (2009) :Uezato, A., et al. Bipolar Disord 11(7):711-725(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Oni-Orisan, A., et al. Biol. Psychiatry 63(8):766-775(2008)
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