|Other Names||Transcription factor Sp2, SP2, KIAA0048|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13121b was selected from the C-term region of SP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Sp subfamily of Sp/XKLFtranscription factors. Sp family proteins are sequence-specificDNA-binding proteins characterized by an amino-terminaltrans-activation domain and three carboxy-terminal zinc fingermotifs. This protein contains the least conserved DNA-bindingdomain within the Sp subfamily of proteins, and its DNA sequencespecificity differs from the other Sp proteins. It localizesprimarily within subnuclear foci associated with the nuclearmatrix, and can activate or in some cases repress expression fromdifferent promoters.
Ito, H., et al. Biochim. Biophys. Acta 1789 (11-12), 681-690 (2009) :Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Letourneur, M., et al. Mol. Immunol. 46 (11-12), 2151-2160 (2009) :Sun, J.M., et al. J. Biol. Chem. 282(45):33227-33236(2007)Das, A., et al. J. Biol. Chem. 281(51):39105-39113(2006)
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